Showing posts with label biology. Show all posts
Showing posts with label biology. Show all posts

Do you want to live forever? - Aubrey De Gray

This is a fascinating documentary about Aubrey De Grey, the eccentric computer scientist turned biologist who predicts that we will be able to live forever in the foreseeable future.  The documentary covers a lot of ground including the scientific debate over the validity of his claims, the ethical issues, including overpopulation, and his underlying psychology and passion.

It mentions the M Prize (Methuselah Prize) which offers several million dollars to anyone who can double life span of a middle aged mouse. It also touches on the tradition of prizes to spur scientific advancement including the Orteig Prize that resulted in Charles Lindbergh crossing the Atlantic Ocean in a solo non-stop flight. It makes me think of other prizes like the X Prize, which, among other things, has challenged people to build private space ships and was won in 2004. It also brings to mind the google lunar x prize which is so far unaccomplished.

It takes you on  a tour of Alcor, a company that uses Cryonics to store your body (or just your head) after you die.

It also mentions the diet caloric restriction (CR) that claims to extend life expectancy. CR is also mentioned in the fascinating book, Microtrends.

Regarding the scientific debate, it's largely inconclusive.  There is a lot of anecdotal evidence that increased life expectancy is possible.  Currently the record for a human is 122 years old held by Jeanne Calment. The average life expectancy of some tortoises is 200 years. Then there is hydra, which regenerates and never dies.  The documentary is light on the actual science which is extremely complex...  although you can read up on SENS (Strategies for Engineered Negligible Senescense) , his plan for curing human aging.

One striking point made in the documentary is a lot of the most high profile people that believe his claims are involved in computer science, like Ray Kurzweil, and Marvin Minskey, not biology. His critics claim he is offering psuedo-science and  invoke an interesting term coined by Richard Feynman,  cargo cult science.  That is where primitive tribes near landing strips built their own landing strips and towers hoping planes would come. 


Life Span

"Maximum life span for humans has remained about 115−120 calendar years throughout recorded history, despite steady improvements in life expectancy. " - from wikipedia on maximum life span

The limiting factor in life expectancy is related to cellular degeneration, and there is a study that the protein telomeras could extend life expectancy. "As we age, and our cells divide, these caps become frayed and shorter and eventually are so damaged that the cell dies. Scientists believe boosting our natural levels of telomerase could rejuvenate them."

Someone once described it to me by saying our cells make copies of copies and like a cassette tape they eventually degenerate.   

There are a lot of theories about aging and cellular degeneration and life extension, including lowerig caloric intake and anti-oxidants to reduce free radicals.

First transplant from organ grown in lab

In England today they performed a transplant from an organ grown in a lab using the patient's own stem cells.  Because of this advance, the patient won't have to take anti-rejection drugs.  In this case a graft from a donor was used, but eventually donors won't be needed.  Soon I won't have to feel guilty about not being an organ donor.

http://www.telegraph.co.uk/health/healthnews/3479613/British-doctors-help-perform-worlds-first-transplant-of-a-whole-organ-grown-in-lab.html